Read 21 to 30 question answer on this link-
CSIR-UGC NET/JRF LIFE SCIENCE EXAM.DECEMBER 2014 QUESTION NO. 21 TO 30 WITH SOLUTION
Q.31 A patient with ER+/PR+ breast cancer was cured with a drug 'T', whereas a second patient did not respond to 'T'. Which one of the following is the best therapy that you should suggest for the second patient?
(a) Surgery,the followed by HER-2/neu targeted drugs
(b) A drug that targets triple negative (ER-/PR-/HER-2-) breast cancer.
(c)Radiation,followed by drug 'T'
(d)Surgery,followed by radiation only
Answer-B
Description-1st patient 2nd patient
ER+/PR+ Breast cancer No response to drug 'T'
PR=Progestrone receptor
ER=Estrogen receptor
HER-2=Human epidermal growth factor receptor
Therefore, a drug, which targets ER-,PR-,HER- breast cancer will be successful and effective drug for both the patients.
Q32.If you run a pentavalent IgM through SDS-polyacrylamide gel electrophoresis,bow many bands you are supposed to get by Western blottng using alkaline phosphatase conjugated secondary antibody?
(a)Five (b)Four
(c)Three (d)One
Answer-D
Description-SDS causes multimeric protein yo break into single subunits.
Q33.The splitting or migration or one sheet of cells into two sheets as seen during hypoblast formation in bird embroygenesis is termed as-
(a)delamination (b) ingression
(c)involution (d)invagination
Answer-A
Description-Splitting or migration of sheet of cells on to 2 sheets of cells delamination.
Q34. Which of the following statements about meiosis is not true?
(a) Kinetochores of sister chromatids attech to opposite poles in meiosis 1
(b) Kinetochores of sister chromatids attech to opposite poles in meiosis II
(c) Chiasma is formed in prophase I
(d) Homologous chromosomes are segregated in meiosis I
Answer-A
Description- Kinetochores of Non sister chromatids attach to opposite poles in meiosis I.
Q35.In chloroplast, the site of coupled oxidation-reduction reactions is the-
(a)outer membrane (b) inner membrane
(c)thylakoid space (d) stromal space
Answer-C
Description- In chloroplast site of coupled oxidation reduction is thylakoid spaces.
Q36.Lens formation requires sequenitial events whereby the anterior neural plate signals the anterior ectoderm to promote secretion of Pax 6, which renders the anterior ectoderm more receptive to secretions from the optic vesicle. The above can be best explained by which of the following phenomenon?
(a) Instructive interactions only
(b) epithelial-Mesenchymal interaction
(c) Permissive interactions
(d) Induction and competence
Answer-D
Q37.The group of cells of amphibian blastula capable of inducing the organizer is called as-
(a) Hensen's node
(b) Nieuwkoop centre
(c) Dorsal blastopore lip
(d) Hypoblast
Answer-B
Description- Group of cells in amphibians blastula
↓
Inducing organizer
Q38. Glycosaminoglycans are usually linked to proteins to form proteoglycans Which of the following is not a proteoglyean?
(a) Hyaluronan (b) Aggrecan
(c) Betaglycan (d) Syndecan-I
Answer-A
Description- Hyaluronan is a Glycosaminoglycan and not a proteoglycan.
Q39.Which one of the following statements regarding seed germination of a wild type plant is not correct?
(a) Low ABA and high bioachtive GA can break seed dormancy
(b) Light accompanied with high temperature can break seed dormancy
(c) GA induce synthesis of hydrolytic enzymes in cereal grains
(d) Degradation of carbohydrates and storage proteins provide nourishment and energy to support seeding growth
Answer-B
Description- Light accomplished with increase in temp. can break seed dormancy
Q40.Some T lymphocytes respond to antigenic stimulation by synthesizing a growth factor that causes T cell proliferation thereby increasing the responsive T lymphocytes resulting in amplification of the immune response. This is an example of-
(a) endocrine signalling
(b) paracrine signalling
(c) autocrine signalling
(d) cyclic signalling
Answer-C
Read next 41 to 50 question answer on this link-
CSIR-UGC NET/JRF LIFE SCIENCE EXAM.DECEMBER 2014 PAPER QUESTION NO. 41 TO 50 WITH SOLUTION
CSIR-UGC NET/JRF LIFE SCIENCE EXAM.DECEMBER 2014 QUESTION NO. 21 TO 30 WITH SOLUTION
Q.31 A patient with ER+/PR+ breast cancer was cured with a drug 'T', whereas a second patient did not respond to 'T'. Which one of the following is the best therapy that you should suggest for the second patient?
(a) Surgery,the followed by HER-2/neu targeted drugs
(b) A drug that targets triple negative (ER-/PR-/HER-2-) breast cancer.
(c)Radiation,followed by drug 'T'
(d)Surgery,followed by radiation only
Answer-B
Description-1st patient 2nd patient
ER+/PR+ Breast cancer No response to drug 'T'
PR=Progestrone receptor
ER=Estrogen receptor
HER-2=Human epidermal growth factor receptor
Therefore, a drug, which targets ER-,PR-,HER- breast cancer will be successful and effective drug for both the patients.
Q32.If you run a pentavalent IgM through SDS-polyacrylamide gel electrophoresis,bow many bands you are supposed to get by Western blottng using alkaline phosphatase conjugated secondary antibody?
(a)Five (b)Four
(c)Three (d)One
Answer-D
Description-SDS causes multimeric protein yo break into single subunits.
Q33.The splitting or migration or one sheet of cells into two sheets as seen during hypoblast formation in bird embroygenesis is termed as-
(a)delamination (b) ingression
(c)involution (d)invagination
Answer-A
Description-Splitting or migration of sheet of cells on to 2 sheets of cells delamination.
Q34. Which of the following statements about meiosis is not true?
(a) Kinetochores of sister chromatids attech to opposite poles in meiosis 1
(b) Kinetochores of sister chromatids attech to opposite poles in meiosis II
(c) Chiasma is formed in prophase I
(d) Homologous chromosomes are segregated in meiosis I
Answer-A
Description- Kinetochores of Non sister chromatids attach to opposite poles in meiosis I.
Q35.In chloroplast, the site of coupled oxidation-reduction reactions is the-
(a)outer membrane (b) inner membrane
(c)thylakoid space (d) stromal space
Answer-C
Q36.Lens formation requires sequenitial events whereby the anterior neural plate signals the anterior ectoderm to promote secretion of Pax 6, which renders the anterior ectoderm more receptive to secretions from the optic vesicle. The above can be best explained by which of the following phenomenon?
(a) Instructive interactions only
(b) epithelial-Mesenchymal interaction
(c) Permissive interactions
(d) Induction and competence
Answer-D
Q37.The group of cells of amphibian blastula capable of inducing the organizer is called as-
(a) Hensen's node
(b) Nieuwkoop centre
(c) Dorsal blastopore lip
(d) Hypoblast
Answer-B
Description- Group of cells in amphibians blastula
↓
Inducing organizer
Q38. Glycosaminoglycans are usually linked to proteins to form proteoglycans Which of the following is not a proteoglyean?
(a) Hyaluronan (b) Aggrecan
(c) Betaglycan (d) Syndecan-I
Answer-A
Description- Hyaluronan is a Glycosaminoglycan and not a proteoglycan.
Q39.Which one of the following statements regarding seed germination of a wild type plant is not correct?
(a) Low ABA and high bioachtive GA can break seed dormancy
(b) Light accompanied with high temperature can break seed dormancy
(c) GA induce synthesis of hydrolytic enzymes in cereal grains
(d) Degradation of carbohydrates and storage proteins provide nourishment and energy to support seeding growth
Answer-B
Description- Light accomplished with increase in temp. can break seed dormancy
Q40.Some T lymphocytes respond to antigenic stimulation by synthesizing a growth factor that causes T cell proliferation thereby increasing the responsive T lymphocytes resulting in amplification of the immune response. This is an example of-
(a) endocrine signalling
(b) paracrine signalling
(c) autocrine signalling
(d) cyclic signalling
Answer-C
Read next 41 to 50 question answer on this link-
CSIR-UGC NET/JRF LIFE SCIENCE EXAM.DECEMBER 2014 PAPER QUESTION NO. 41 TO 50 WITH SOLUTION
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